Blar i forfatter "Lomet, Didier"

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    • Anti-angiogenic VEGFAxxxb transcripts are not expressed in the medio-basal hypothalamus of the seasonal sheep 

      Lomet, Didier; Piegu, Benoit; Wood, Shona Hiedi; Dardente, Hugues (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-10)
      This study investigated Vegfa expression in the pars tuberalis (PT) of the pituitary and medio-basal hypothalamus (MBH) of sheep, across seasons and reproductive states. It has recently been proposed that season impacts alternative splicing of Vegfa mRNA in the PT, which shifts the balance between angiogenic VEGFAxxx and anti-angiogenic VEGFAxxxb isoforms (with xxx the number of amino acids of the ...

    • Circuit-level analysis identifies target genes of sex steroids in ewe seasonal breeding 

      Lomet, Didier; Druart, Xavier; Hazlerigg, David; Beltramo, Massimiliano; Dardente, Hugues (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-15)
      Thyroid hormone (TH) and estradiol (E2) direct seasonal switches in ovine reproductive physiology. In sheep, as in other mammals and birds, control of thyrotropin (TSH) production by the pars tuberalis (PT) links photoperiod responsiveness to seasonal breeding. PT-derived TSH governs opposite seasonal patterns of the TH deiodinases Dio2/Dio3 expression in tanycytes of the neighboring medio-basal ...

    • Discontinuity in the molecular neuroendocrine response to increasing daylengths in Ile-de-France ewes: Is transient Dio2 induction a key feature of circannual timing? 

      Dardente, Hugues; Lomet, Didier; Chesneau, Didier; Pellicer-Rubio, Maria-Teresa; Hazlerigg, David (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-24)
      In mammals, melatonin is responsible for the synchronisation of seasonal cycles to the solar year. Melatonin is secreted by the pineal gland with a profile reflecting the duration of the night and acts via the pituitary pars tuberalis (PT), which in turn modulates hypothalamic thyroid hormone status via seasonal changes in the production of locally‐acting thyrotrophin. Recently, we demonstrated that, ...